Interleukin 3 Perfusion in W / W ° Mice Allows the Development of Macroscopic Hematopoietic Spleen Colonies and Restores Cutaneous Mast Cell
نویسندگان
چکیده
The genetically anemic W/W° mice are characterized by the inability of their bone marrow cells to form macroscopic pluripotent hematopoietic colonies in the spleen ofirradiated recipients upon transfer (colony-forming units) . Furthermore, they almost totally lack mast cells, notably in the skin . In the present study, we have tested the effect of recombinant murine interleukin 3 (rmIIr3) on W/W° mice hematopoiesis . Transfer of W/W° bone marrow cells into lethally irradiated recipients perfused with rmIlr3 is followed by the appearance of macroscopic spleen colonies. Moreover, perfusion of rmIL3 in W/W° mice: (a) restores almost normal total numbers ofhematopoietic precursors (colony-forming cells), but without modification of anemia; and (b) leads to the appearance of a normal number of mastocytes in the skin .
منابع مشابه
Interleukin 3 perfusion in W/Wv mice allows the development of macroscopic hematopoietic spleen colonies and restores cutaneous mast cell number
The genetically anemic W/Wv mice are characterized by the inability of their bone marrow cells to form macroscopic pluripotent hematopoietic colonies in the spleen of irradiated recipients upon transfer (colony-forming units). Furthermore, they almost totally lack mast cells, notably in the skin. In the present study, we have tested the effect of recombinant murine interleukin 3 (rmIL-3) on W/W...
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